A decided underdog, the Titans led for a good chunk of the game at Arrowhead Stadium.
But the Chiefs rallied to win 20-17 in overtime, and they snapped Tennessee's five-game winning streak in the process.
"It's very disappointing," Titans coach Mike Vrabel said. "I feel terrible for the players that compete, that put so much into this and play through pain, through discomfort, through any situation. I am lucky that I get to coach them – they fight.